Scale science with confidence.

With expertise spanning Pharmaceutical Sciences and Technology, we work alongside our clients to shape development strategy and implement comprehensive analyses across all stages of drug development.

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Solutions

Tailored solutions across domains⁠

Drawing on expertise in technology and pharmaceutical sciences, A2-Ai offers comprehensive, technology-enabled solutions for complex data management and analysis problems. Composed of modular toolboxes and customizable consulting and analysis services, our offerings are tailored to fit the client, not the other way around.

Science

Strategic consulting and incisive data analysis, from preclinical and first-in-human dose-selection, to the submission that puts your drug on the market.

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Technology

Validated compute, a managed package ecosystem and a publishing platform — reproducibility and rigor start with your data ecosystem.

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Featured services

Where most programs start⁠

Scientific

Clinical pharmacology

Expert guidance on regulatory and development decision-making across all phases

Submission support
Document authorship/co-authorship
Regulatory meeting attendance and support
Strategy and guidance

Scientific

Noncompartmental analysis

Reproducible, submission-ready descriptive analyses with validated domains

Validated domain generation
Submission-ready analyses and documentation

Scientific

Pharmacometrics

Quantitative modeling to enable informed decision-making across phases

population Pharmacokinetic (popPK) modeling
Pharmacokinetic/Pharmacodynamic (PK/PD) analysis
Exposure-Response (ER) analysis
Physiologically based pharmacokinetic (PBPK) analysis

Technology

Application and dashboard development

Custom Shiny apps and dashboards that turn complex data into faster decisions

Shiny
2-day turnaround
Dashboards

Technology

Posit Team infrastructure support

Posit Team infrastructure configured for reliable, production scale scientific work

Posit
Connect
Workbench
PPM

Client testimonies

Partnerships, in our clients’ words⁠

We take pride in forging real partnerships undergirded by mutual respect and shared goals. Here’s what our clients have to say about the A2-Ai experience:

“You’re like a unicorn — a [team] that can interface with every single group: the business, QA, IT and leadership, to get stuff done.”

— Large pharma sponsor

“A2-Ai provided key support drafting our Phase 1 clinical synopsis — the dose escalation and the pilot food-effect cohort. They drew on extensive experience running such studies to deliver a synopsis that was clear, easy to follow, patient-friendly, and most importantly can save time and money in advancement of the compound.”

— Early-stage biotech sponsor

“It’s rare we find and get to work with consultants who truly feel like part of the team and share the commitment we have to our program. We could trust you to deliver high quality guidance and high quality written documents with minimal oversight — and you took a vested interest in making sure our NDA was as compelling as possible, as opposed to just focusing on completing a given task.”

— Clinical-stage biotech, NDA program

“With your technology, I feel like I went from riding a donkey to driving a Tesla.”

— Mid-size sponsor

“In my nearly 33 years in pharma, I can say honestly no CRO or contractor surpassed the quality, responsiveness, or collaborative nature of you and your team. Truly a great group.”

— Pharma R&D leader, retired

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