Calculate exposures needed to achieve common effect thresholds based on simple or sigmoidal maximum effect (Emax) models. Enter EC 50/IC50, Emax/Imax, and the Hill coefficient (n) to compute thresholds from 10% through 99%, including 95%.
Calculate exposures needed to achieve common effect thresholds based on simple or sigmoidal maximum effect (Emax) models.
Note: Calculations are based on the sigmoidal maximum effect model and report results for thresholds 10–90%, 95%, and 99%. Verify assumptions and units for your specific use case.
Convert clearance (CL) and volume (V) parameters for 2- and 3-compartment mammillary PK models to corresponding micro- and macro-rate constants. Derived half-lives and VSS are also output.