Bottom-up modeling integrating biological knowledge and in vitro data
Unlock mechanistic insight with physiologically based pharmacokinetics (PBPK) and quantitative systems pharmacology (QSP), and build models bottom-up from biological knowledge and calibrated to your in vitro data. Mechanism-based models facilitate comprehensive assessment of drug-drug interactions (DDI) and the impact of eliminating organ impairment, often avoiding the need for dedicated clinical studies, and support biological translation to new patient populations or subpopulations.
What's included
- PBPK and QSP modeling
- DDI assessment
- Organ impairment assessment
- Pediatric Simulation
- Submission-ready documentation
C-QT modeling for TQT study waivers
Strategic and quantitative support for your thorough QT waiver
Clinical trial design
Integrate quantitative insights with our expertise to de-risk clinical trial design
Exposure-response modeling of efficacy and safety
Quantitative models to describe and predict your drug’s efficacy and safety
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