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A Year of Science at A2-Ai: Reflections from 2025

Meg Gonsalves · December 26, 2025

Science

C-QT modeling for TQT study waivers
Clinical pharmacology
Clinical trial design
Exposure-response modeling of efficacy and safety
IND support
Mechanistic modeling (PBPK and QSP)
MIDD Paired Meeting Program
NDA/BLA support
Noncompartmental analysis
Pharmacokinetic and pharmacodynamic modeling and simulation
Pharmacometrics
Project Optimus
Translational modeling for FIH dose selection

Technology

Application and dashboard development
Posit Team infrastructure support
SAS migration support
Support services
Technology services
Training and enablement
Validation services

Software

Products

A2-Ai Cloud
Alexandria
PRISM
Sage AI

Open source

reportifyr
rv
dvs

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Leadership
Careers
Contact

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Blog
Case studies
ER thresholds
Multi-compartment PK

Topics

Pharmacometrics
Clinical pharmacology
Infrastructure
R
Regulatory initiatives
Shiny
Noncompartmental analysis
Posit

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