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2025adamadmeagingaiallometric scalinganimal modelsanimal testingannualapproval processbetween-subject variabilitybody weightcardiac safetycdiscclinical pharmacologyclinical researchclinical trialscloud platformcross-speciesdatadata analysisdmtdose escalationdose selectiondrug developmenteegeligibility criteriaexploratory data analysisexposureexposure responsefdafda guidancefixed effects modelingindmachine learningmetronidazolemiddminimal physiologically-based pharmacokinetic modelingmixed effects modelingmodelingmodeling mondaymonolixmpbpk allometric meta-analysisnaïve poolingncaneurochemistryneurosciencenoncompartmental analysisnonmemolder adultsopen sourcepackagepbpkpediatric populationspharmacokineticspharmacometricspkpkpdpmxpoppkpopulation pharmacokineticspreclinicalpsychedelicsqtcrrecruitmentreportingresearchreviewsciencesdtmsimulationssoftwarestudy designsubmissionstechnologytqt waivervirtual populations