Service

Preclinical Support

Nonclinical Development

A2-Ai can engage with you to perform gap analyses and design of IND-enabling packages (pharmacology, DMPK, and toxicology), from animal protocol development to quantitative analysis and reporting. We support a range of analyses including modeling of animal data (including PBPK), inter-species simulations, and determination of your First in Human (FIH) dose.

Bioanalytical Development

Partner with A2-Ai for vendor selection, oversight, and design of development stage-appropriate analytical methods. We can help with method development and validation support from discovery screening to late-stage clinical studies. Work with us for complete bioanalytical method development supporting all therapy modalities:

  • Small molecules
  • Antibodies
  • ADCs
  • Proteins
  • Nucleotides
  • Cell therapies

We are experienced with many modalities, including:

  • Ligand-binding assays, PK and ADA
  • LC-MS methods, small and large molecules
  • Quantitative PCR methods
  • Flow cytometry, PK and PD

IND Services

Our experienced Clinical Pharmacologists and Medical Oncologists will work with you to design your First in Patient (FIP)/First in Human (FIH) study as a part of the IND package. Our Medical Writers will work with your Subject Matter Experts to finalize the IND so that it is ready to be submitted to the FDA (or other regulatory body). The A2-Ai team is available for writing the pre-IND Briefing Document as well as attending the pre-IND meeting with the FDA to defend the start dose and the dose escalation strategy (Phase 1A).